[Research]An emerging indication for desloratadine is in the treatment of acne, as an inexpensive adjuvant to isotretinoin and possibly as maintenance therapy or monotherapy.

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Desloratidine wikiSo I've used this as an antihistamine in the past and just came across this gem in the wiki.reference:Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study.RESULTS: At week 12, compared with isotretinoin only group, isotretinoin with additional antihistamine group showed more statistically significant decrease in acne lesion counts (non-inflammatory lesions: 44.8% vs. 17.8%; inflammatory lesions: 55.8% vs. 22.9%; total lesions: 45.6% vs. 18.7%; all P < 0.05). Significant decrease was also observed in the score of global acne grading system and the measured value of sebum and erythema. Moreover, acne flare during the treatment occurred less frequently and adverse events of isotretinoin were more tolerable in additional antihistamine group.There's also a second reference in the wiki to this buzzfeed-worthy article Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris but there's little to glean from the paywall.But ya. Searching up 'desloratidine' on r/SCA gives 0 results so I thought this might be informative/helpful to some, particularly those undergoing accutane, and potentially more generally to allergy sufferers!Maybe we could lead this into some kind discussion on antihistamines/allergies/acne.word of caution/post-note desloratidine is a newer generation antihistamine touted as being 'non-drowsy', compared to say, Benadryl, which is fairly sedating. That being said, don't stuff your face with these things if you REQUIRE HIGH VIGILANCE
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