[RESEARCH] New Tretinoin LOTION formulation, new acne treatments

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This information has been taken from Medscape and requires an account to access. I'm going to summarize below some key information from the presentation. I hope people find this interesting and become more up-to-date with recent advances in dermatology.​New Topical Retinoid - Tretinoin 0.05% Lotion ( https://www.rxlist.com/altreno-drug.htm, https://ir.bauschhealth.com/news-releases/2018/10-30-2018-120452296 )Two phase 3 studies (N=1640), patients with moderate to severe acne, age 9-58 yearsEvaluated efficacy, safety, and tolerability of tretinoin 0.05% lotion vs vehicleInflammatory and non-inflammatory lesion counts and acne severity evaluatedStatistically significant results in a cosmetically more elegant formula (!), effective for inflammatory and non-inflammatory lesions, reducing acne severityInactive ingredients: benzyl alcohol, butylated hydroxytoluene, carbomer copolymer type B (Pemulen TR-1), carbomer homopolymer type A (Carbopol 981), glycerin, methylparaben, mineral oil, octoxynol-9, purified water, sodium hyaluronate, soluble collagen and trolamine.​New topical antibiotic - 4% Minocycline foam ( https://www.sciencedirect.com/science/article/pii/S0190962218324745?via%3Dihub )2 identical phase 3 trials examined topical minocycline 4% foam in patients with moderate to severe acne (N=961)Patients were randomized 2:1 to once daily minocycline 4% foam vs vehicle for 12 weeksCoprimary endpoints = change in inflammatory lesion count compared to baselineTreatment success measured by an IGA of 0 or 1/clear or almost clear with a >2-grade improvement at week 12Monocycline-treated patients has significantly greater reduction in inflammatory lesions from baselinePossible replacement for systemic antibiotics?​Completely New Retinoid - Trifarotene 50mcg/g Cream ( https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.16733 )Efficacy of trifarotene in patients moderate with facial and truncal acne vulgaris as assessed by the IGA (face) and PGA (trunk - meaning chest and back (!) )2 parallel multicenter trials in patients age >9 (N=1200)Significant difference in IGA and PGA in patients who received trifarotene vs placebo, P<.001​New Topical Anti-Androgen - Clascoterone 1% Cream ( https://sci-hub.tw/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2133.2011.10332.x )Androgen antagonist, competes with androgen receptor3x more potent than flutamide, 2x more than finasteride, equal to cyproterone acetateHas been shown to limit sebum production in vitro and down regulate proinflammatory cytokinesAt week 12, significant benefit compared with vehicle in IGA treatment success (clear, almost clear), non-inflammatory lesion counts (absolute reduction), inflammatory lesion counts (absolute reduction)​New Oral Antibiotic - Sarecycline ( https://www.drugbank.ca/drugs/DB12035 )Tetracycline-classAnti-inflammatory properties and narrower spectrum of activityApproved in Oct 2018 in patients > age 9, patients with moderate-severe facial acne, weight based dosing 1.5mg/kg/day, once daily with or without foodEndpoint: >2-grade improvement in IGA and clear/almost clearAt week 12, for facial acne, IGA success, inflammatory lesion reduction; for truncal acne, IGA success for chest and backNo vertigo or tinnitus TEAEs, minor increase in dizziness AEs, sunburn and photosensitivity were uncommon, low rates of vaginal yeast infections typically associated with oral antibiotics in female subjectsEffective at 3 weeks (!)​TLDR: A hopeful new tretinoin formulation in a more tolerable vehicle, new topical and oral antibiotics with fast results, entirely new retinoid aimed at treating chest and back acne.
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