[Research] How far do topical retinoids travel/communicate throughout the skin?

Beauty Tips For Body Care
I'm kinda on a mission to determine the effects topical retinoids can have on our Meibomian glands, and their relation to meibomian gland dysfuction aka dry eye disease. While there has been a lot of research done on systemic forms of retinoids taken orally and their proven links to meibomian gland dysfuction and atrophy. Little to negligible research has conducted into the effects topical retinoids can have on our ocular health.My basic understanding of how Retinoids work is that they communicate cell by cell and have signalling effects on the proliferation and differentiation of these cells. I'm wondering is there any literature that talks about how far they can travel/migrate throughout the skin? I'm wondering for example, if you apply topical retinoids (in my case Adapalene 0.1) on the forehead is there anyway the Retinoids could somehow effect the meibomian glands in the eyes? Can topical Retinoids travel that far?
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Submitted by PowerfulDivide