Friday, 7 April 2017

[Research] Use of Nicotinamide (Niacinamide) in Dermatology (Review Article)

Beauty Tips For Body Care
Recently I became interested in the use of nicotinamide (aka niacinamide) in terms of what it is purported to accomplish, whether it actually does that, and what kind of benefits I could expect to see from including it in my routine. I have been looking into The Ordinary line as it has been talked about a lot here lately and on youtube from some of my favorite skincare reviewers. Many of them highly recommend the 10% niacinamide + 1% zinc solution, and I know that on SCA everyone talks about how they want/are glad to have niacinamide in their moisturizers and other products.So anyway, I went to the literature to answer my question (after first searching the sidebar and posts in the sub of course!). Recently, this review article was published which provides a nice summary of some of the literature to date on the use of niacinamide.If you can't access the article fully or just don't want to read it, here's a little summary:taken orally (500 mg 2x daily) it has been shown to decrease the development of new non-melanoma skin cancers by 23% (P=0.02)also taken orally, it may be used to treat blistering disorders such as bullous pemphigoid (an autoimmune hypersensitivity reaction)several studies of topical application of niacinamide (varying in concentrations of 2-4%) have shown comparative improvement in acne vulgaris and reduced sebum production or possibly excretionone study showed that niacinamide 4% topical applied twice daily had results comparable to that of clindamycin 1%a double blind study comparing niacinamide 4% to hydroquinone 4% showed similar improvements to melasma, with much less adverse effects from niacinamidea double blind randomized controlled (RCT) study showed a significant improvement in facial spots and pigmentation compared to placebo in a group using niacinamide 4% (P <0.05)a double blind split-face RCT showed significant improvement in skin wrinkles (P <0.001) and skin texture (P <0.05) on skin treated with niacinamide 4% compared to placebosome studies have shown improvements in pruritic (itching) conditions like atopic dermatitis and psoriasis with topical application of niacinamideI think this is something I'm going to seriously consider adding to my routine, ideally at an effective percentage which appears to be around at least 2-4%. Hope this information helps anyone considering using these types of products!Here's the full citation for the article: Forbat, E., Al-Niaimi, F. and Ali, F. R. (2017), Use of nicotinamide in dermatology. Clin Exp Dermatol, 42: 137–144. doi:10.1111/ced.13021Cheers!
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