[Research] Topical melatonin may reduce UV induced skin damage when applied before exposure to the sun

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Relevant excerpt from article:"Clinically, topically applied 0.5% melatonin reduces UV-erythema when administered before, but not when applied after UV-irradiation (126,127). This was confirmed by another group showing that not only melatonin but also other antioxidants (vitamin E and vitamin C) have no effect on UV-erythema when administered after UV-irradiation, irrespective of the time course of application (128). Associated immunological skin responses, as exemplified by UV-induced suppression of the Mantoux response, are also not inhibited by melatonin when applied after UV-exposure (129). This indicates that the UV-induced free radical formation in skin is an immediate event which can only be antagonized by antioxidants that are already present at the target sites and at the time point of UV-exposure."I think this really highlights the importance of preventative skin care, like applying antioxidant serums and sunscreen before stepping out, because healing damage caused by ultraviolet rays is much more difficult and complicated than simply avoiding it in the first place.Citation: Fischer, Tobias W., Andrzej Slominski, Michal A. Zmijewski, Russel J. Reiter, and Ralf Paus. "Melatonin as a Major Skin Protectant: From Free Radical Scavenging to DNA Damage Repair." Experimental Dermatology 17.9 (2008): 713-30. Wiley Online Library. Web.
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