[Research] No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

Beauty Tips For Body Care
Data from in-vitro experiments suggest vitamin D reduces the rate of skin aging whereas population studies suggest the opposite, most likely due to confounding by UV-exposure.We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian Randomization Study. In the Rotterdam Study (N=3,831; 58.2% women, median age 66.5 years) and Leiden Longevity Study (N=661; 50.5% women, median age 63.1 years), facial skin aging features (perceived age, wrinkling, pigmented spots) were assessed either manually or digitally. Associations between 25-hydroxyvitamin D and skin aging features were tested by multivariable linear regression.Mendelian Randomization analyses were performed using SNPs identified from previous genome-wide association studies. After meta-analysis of the two cohorts, we observed that higher serum 25-hydroxyvitamin D was associated with a higher perceived age (p-value=3.6e-7), more skin wrinkling (p-value=2.6e-16), but not with more pigmented spots (p-value=0.30).In contrast, genetically determined 25-hydroxyvitamin D concentration was not associated with any skin aging feature (p-values>0.05). Furthermore, a genetically determined higher degree of pigmented spots was not associated with higher 25-hydroxyvitamin D (p-values>0.05).Our study did not indicate that associations between 25-hydroxyvitamin D and features of skin aging are causal.Paper Link
Girls Blog 2015
Submitted by kindofstephen